NS3861

• Catalog Number: orb1298032
• Category: Small Molecules
• Description: NS3861
• Purity: 99.40%
• MW: 284.22
• Biological Activity: NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-containing receptors. The maximal efficacy of NS3861 appeared solely dependent on the nature of the ligand-binding domain. Furthermore, a principal subunit serine to threonine substitution may explain the lack of NS3861 activation at α4-containing receptors.
• CAS Number: [216853-59-7]
• Formula: C₁₂H₁₄BrNS
• SMILES: CN1C2CCC1C=C(C2)c1sccc1Br
• Storage: -20°C
• Note: For research use only