NS309

SKU: orb1302710

Description

NS309 is a potent, selective activator of SK (KCa2) and IK (KCa3.1) potassium channels, with significantly greater potency than 1-EBIO. It is widely used in neuroscience and electrophysiology research to study SK channel-mediated afterhyperpolarization and neuronal excitability in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 18711-16-5
• MW: 231.04
• Purity: 97.55%
• Formula: C₈H₄Cl₂N₂O₂
• SMILES: ON=C1C(=O)Nc2c1ccc(Cl)c2Cl
• Target: EGFR,Potassium Channel
• Solubility: DMSO:45 mg/mL (194.77 mM)

Bioactivity

• Target IC50:
  ERG (human):1 µM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium Channel, PotassiumChannel, SCI/R, spinal, OAB, overactive, neuronal, ischemia-reperfusion, inhibit, KcsA, NS 309, NS309, NS-309, Inhibitor, hyperexcitability, hERG, injury, erectile, function, bladder, cord

Compound Identifiers

PubChem CID

135502903