NRX-2663

SKU: orb1687855

Description

NRX-2663 is a small molecule that potently enhances the interaction between β-catenin and the SCFβ-TrCP E3 ubiquitin ligase complex, with a reported Kd of 54.8 nM and an EC50 of 22.9 nM. This compound is a valuable research tool for studying Wnt/β-catenin signaling, protein degradation mechanisms, and has utility in both in vitro biochemical assays and cellular models of oncogenesis.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2763260-34-8
• MW: 418.32
• Formula: C₂₀H₁₃F₃N₂O₅
• SMILES: O=C(O)C=1C=CC=C(C1)NC(=O)C=2C(=O)NC(=CC2OC=3C=CC=CC3)C(F)(F)F
• Target: Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137628321