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NRX-252262

SKU: orb1218298

Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM).

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2438637-61-5
MW545.36
Purity>98% (HPLC)
FormulaC23H17Cl2F3N2O4S
SMILESO=C1C(C(N2CC3=C(C=C(OC)C(OC)=C3)C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
TargetSCF(β-TrCP)-E3 ligase
SolubilityDMSO:8 mg/mL (14.67 mM; Need ultrasonic)

Bioactivity

In Vitro
NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    C23H17Cl2F3N2O4S

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Protocol Information

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200 mg
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5 mg
$ 460.00
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100 mg
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