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Nrf2-IN-4 hydrobromide

SKU: orb3174777

Description

Nrf2-IN-4 (Compound PhcY) hydrobromide is an Nrf2 inhibitor that promotes ferroptosis by inhibiting NRF2. It disrupts cellular iron homeostasis, leading to ferritin degradation and ultimately triggering ferroptosis. Additionally, Nrf2-IN-4 hydrobromide induces lysosomal activation by enhancing iron-dependent reactive oxygen species (ROS) production and lysosomal acidification. This compound shows significant antitumor effects and is applicable in breast cancer research.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

TargetNrf2,Ferroptosis,ROS,ATG

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information