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Nrf2 activator-10

SKU: orb3134464

Description

Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent antioxidant response element (ARE) inducer, with an EC50 of 2.7 μM, and also acts as an Nrf2 activator. It modifies Keap1, preventing the formation of the Cul3-Keap1 ubiquitin ligase complex, thereby activating Nrf2 transcription. Nrf2 activator-10 provides cellular protection against H2O2-induced apoptosis.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number75483-04-4
MW265.692
FormulaC13H12ClNO3
SMILESO=C(C1=C(Cl)C2=C(N(C)C1=O)C=CC=C2)OCC
TargetNrf2,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information