NQDI-1

SKU: orb1304540

Description

NQDI-1 is a selective, cell-permeable inhibitor of apoptosis signal-regulating kinase 1 (ASK1/MAP3K5) with an IC50 of 3 µM. It is a valuable research tool for studying ASK1's role in oxidative stress, apoptosis, and inflammatory pathways in both cellular and animal models of related diseases.

Research Area

Cell Biology, Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 175026-96-7
• MW: 319.3
• Purity: >98%
• Formula: C₁₉H₁₃NO₄
• SMILES: CCOC(=O)c1c2-c3ccccc3C(=O)c3cccc([nH]c1=O)c23
• Target: Kinase
• Solubility: Soluble in DMSO (3 mg/ml)

Bioactivity

• Target IC50:
  MAP3K5:3 μM|ASK1:3 μM|ASK1:500 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, ASK1, Inhibitor, MAP3K, MAP3K5, MAP kinase kinase kinase, MEKK, MAPKKK, NQDI 1, NQDI1, NQDI-1, inhibit

Compound Identifiers

PubChem CID

5522952