NP-1815-PX

SKU: orb1738325

Description

NP-1815-PX is a selective P2X4 receptor antagonist exhibiting anti-inflammatory and analgesic effects. It is utilized in research on chronic pain and airway hyperresponsiveness, supported by in vitro studies demonstrating inhibition of guinea pig tracheal smooth muscle contraction.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1239578-80-3
• MW: 424.41
• Purity: 99.39% (May vary between batches)
• Formula: C₂₁H₁₃N₄NaO₃S
• SMILES: O=C1NC2=C(N(C(C1)=O)C3=CC=CC(C4=NOC([N-]4)=S)=C3)C=CC5=C2C=CC=C5.[Na+]
• Target: P2X Receptor

Bioactivity

• Target IC50:
  P2X4 receptor (human):0.26 μM
• In Vivo:
  In a mouse model of chronic pain, NP-1815-PX inhibited mechanical abnormal pain induced by nerve damage without any change in basal pain sensitivity or motor function. NP-1815-PX showed inhibitory effect on mechanical abnormal pain in a herpes pain model.
• In Vitro:
  NP-1815-PX is a novel selective antagonist of P2X4R. NP-1815-PX effectively inhibited the increase of [Ca2+]i in P2x4R-mediated HP2x4R-1321N1 cells in a concentration-dependent manner, with IC50 value of 0.26 μM for hP2X4R.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY-10-67197, BAY10-67197, BAY106,7197, BAY-106,7197, BAY1067197, BAY 1067197, BAY 10-67197, BAY 106,7197, NP-1815-PX, Neladenoson bialanate., Neladenoson dalanate, P2X Receptor, P2XReceptor

Compound Identifiers

PubChem CID

154731051