NP-004255

SKU: orb1225582

Description

NP-004255 (NP004255, Corilagin) is a small molecule binds specifically to DNA repair protein RAD52 and disrupts the RAD52-ssDNA interaction, inhibits ssDNA binding with IC50 of 1.5 uM

Key Properties

• CAS Number: 23094-69-1
• MW: Formula Weight 634.45
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₂O₁₈
• SMILES: C1C2C(C(C(C(O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)O)OC(=O)C4=CC(=C(C(=C4C5=C(C(=C(C=C5C(=O)O1)O)O)O)O)O)O)O
• Target: DNA Repair Protein
• Solubility: Ethanol: SolubleMethanol: SolublePyridine: Soluble （<1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vivo:
  Animal model: Hep3B hepatocellular carcinoma mouse model. Dosage: 15 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Inhibited tumor growth without toxic effects. Animal model: APAP-induced hepatotoxicity in mice. Dosage: 0, 1, 5, 10, 20 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Decreased APAP-induced serum ALT level, hepatic myeloperoxidase (MPO) activity, cytokines (TNF-α, IL-1β, and IL-6) production, malondialdehyde (MDA) activity, and ERK/JNK MAPK and NF-κB protein expressions.
• In Vitro:
  Cell Viability Assay Cell line: SGC7901 and BGC823 cell. Concentration: 0, 10, 20, 30, 40 and 50 μM. Incubation time: 24 h. Result: Inhibited cell proliferation in a concentration-dependent manner. Western blot analysis. Cell line: SGC7901 and BGC823 cell. Concentration: 0, 10, 20, 30 μM. Incubation time: 24 h. Result: Decreased the protein levels of procaspase-8, -9 and -3 and increased the level of cleaved PARP.

Storage & Handling

• Storage: Store at -20℃. Stable for ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NP004255; Corilagin

CAS No. 23094-69-1

Compound Identifiers

PubChem CID

5089683