Notopterol

SKU: orb1221690

Description

Notopterol is an analgesic compound with anti-inflammatory action isolated from Notopterygium incisum Ting.

Key Properties

• CAS Number: 88206-46-6
• MW: 354.4
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂O₅
• SMILES: CC(=CC(CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C)O)C
• Target: Histamine Receptor
• Solubility: In Vitro: DMSO : 100 mg/mL (282.17 mM)

Bioactivity

• In Vitro:
  notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner. notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner. Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells. Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Notopterol

Quick Database Links

Gene Symbol

Histamine Receptor