NOTA-FAPI

SKU: orb1739820

Description

NOTA-FAPI-4 is a fibroblast activation protein (FAP) inhibitor used as a PET imaging agent. It enables non-invasive visualization and quantification of FAP-expressing cells in vivo, supporting research in oncology, fibrosis, and inflammation for both diagnostic imaging and therapy monitoring in preclinical models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2374782-03-1
• MW: 771.81
• Purity: 99.75% (May vary between batches)
• Formula: C₃₆H₄₇F₂N₉O₈
• SMILES: C(NCC(=O)N1[C@H](C#N)CC(F)(F)C1)(=O)C=2C3=C(C=CC(OCCCN4CCN(C(CN5CCN(CC(O)=O)CCN(CC(O)=O)CC5)=O)CC4)=C3)N=CC2
• Target: Immunology/Inflammation related
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (4.28 mM);DMSO:80 mg/mL (103.65 mM)

Bioactivity

• In Vivo:
  In KM mice, Al18F-NOTA-FAPI demonstrated rapid renal clearance and low uptake in most normal organs. In U87MG tumor-bearing mice, the uptake in the tumor region was relatively high (35.29±1.00%ID/g), with a 33.72% decrease in uptake observed between 1 hour and 4 hours .
  Read more...
• In Vitro:
  In U87MG cells, Al18F-NOTA-FAPI-4 exhibited the highest uptake rate (2.13±0.17 AD%) at 10 minutes, and this uptake could be blocked by unlabeled precursors. The IC50 value of NOTA-FAPI-4 was 1.73±0.93 nM, indicating its high affinity for FAP .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NTFAPI, NOTA-FAPI-04

Compound Identifiers

PubChem CID

139400498