Nosiheptide

SKU: orb1307953

Description

Nosiheptide (Multhiomycin) is a thiopeptide antibiotic from Streptomyces actuosus that inhibits bacterial protein synthesis. Its unique structure features an indole side ring and hydroxylated macrocycle. This compound is used in growth promotion studies and researched in microbiology for its mode of action in vitro.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 56377-79-8
• MW: 1222.36
• Purity: 98.46% (May vary between batches)
• Formula: C₅₁H₄₃N₁₃O₁₂S₆
• SMILES: C\C=C1\NC(=O)C(NC(=O)c2csc(n2)-c2cc(O)c(nc2-c2csc(n2)C2CSC(=O)c3[nH]c4cccc(COC(=O)C(O)CC(NC(=O)c5csc1n5)c1nc(cs1)C(=O)N2)c4c3C)-c1nc(cs1)C(=O)NC(=C)C(N)=O)C(C)O
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:125 mg/mL (102.26 mM)

Bioactivity

• In Vivo:
  Nosiheptide (20 mg/kg; intraperitoneal injection; administered at 1 and 8 hours post-infection; female CD1 mice) significantly protects against mortality, with all 10 treated mice surviving by day 3, compared to 6 out of 10 control mice dying on day 1.
• In Vitro:
  Nosiheptide demonstrates non-toxic behavior towards mammalian cells at concentrations greater than 100 times the minimum inhibitory concentration (MIC) and retains its effectiveness against Staphylococcus aureus in the presence of 20% human serum. It is particularly potent against Enterococcus spp., the hypervirulent BI strain of Clostridium difficile, and displays remarkable activity against all tested strains of Staphylococcus aureus, including those resistant to multiple drugs (MIC values ≤ 0.25 mg/L). Additionally, Nosiheptide exhibits a significantly extended post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus when compared to vancomycin. Through time-kill studies, Nosiheptide has been found to quickly eliminate Staphylococcus aureus in a concentration- and time-dependent manner, achieving a near 2-log reduction at 6 hours with a concentration 10 times the MIC .

Storage & Handling

• Storage: keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RP 9671, RP9671, RP-9671, Inhibitor, Multhiomycin, inhibit, Nosiheptide, Antibiotic, Bacterial

Compound Identifiers

PubChem CID

22833840