NOSH-aspirin

SKU: orb3173937

Description

NOSH-aspirin (NBS-1120) is an orally active hybrid molecule that releases nitric oxide and hydrogen sulfide. It inhibits the proliferation of pancreatic cancer cells and induces apoptosis. In a mouse model of pancreatic cancer, NOSH-aspirin suppresses tumor growth and inhibits NF-κB and FoxM1. Additionally, it alleviates motor deficits and dopaminergic neuronal degeneration in a rat model of Parkinson's disease and reduces neuroinflammation caused by the activation of microglia and astrocytes. NOSH-aspirin is useful for research in cancers such as pancreatic cancer and neurological disorders like Parkinson's disease.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1357362-67-4
• MW: 477.52
• Formula: C₂₀H₁₅NO₇S₃
• SMILES: O=C(OC=1C=CC(=CC1)C=2SSC(=S)C2)C=3C=CC=CC3OC(=O)CCCON(=O)=O
• Target: Apoptosis,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,NF-κB