Norverapamil hydrochloride

SKU: orb1307955

Description

Norverapamil hydrochloride

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 67812-42-4
• MW: 477.04
• Purity: 99.63%
• Formula: C₂₆H₃₇ClN₂O₄
• SMILES: Cl.COc1ccc(CCNCCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
• Target: Drug Metabolite,P-gp,Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.19 mM);H2O:50 mg/mL (104.81 mM);DMSO:31 mg/mL (64.98 mM)

Bioactivity

• In Vivo:
  Norverapamil hydrochloride (9 mg/kg; p.o.) exhibits a terminal half-life of 9.4 hours, an AUC of 260 ng ml−1 h, and a Cmax of 41.6 ng/mL.
• In Vitro:
  Norverapamil inhibits macrophage-induced tolerance and attains serum levels comparable to verapamil. Both verapamil and its primary metabolite, Norverapamil, are identified as mechanism-based inhibitors and substrates of CYP3A, exhibiting non-linear pharmacokinetics clinically. Furthermore, ((±)-Norverapamil hydrochloride) proves as effective as verapamil in inhibiting tolerance and killing intracellular M. tuberculosis in monotherapy, matching its efficacy against isoniazid and rifampicin tolerance .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(±)-Norverapamil, (±)-Norverapamil hydrochloride, ABCB1, Ca channels, Calcium channel, Calcium channel blocker, Calcium Channel, Ca2+ channels, DrugMetabolite, Drug Metabolite, D591, D-591, D591 Hydrochloride, D591 hydrochloride, D-591 Hydrochloride, D 591, D 591 Hydrochloride, Cluster of differentiation 243, CD243, CalciumChannel, MDR1, efflux, Inhibitor, Norverapamil, Norverapamil Hydrochloride, Norverapamil hydrochloride, inhibit, Multidrug resistance protein 1, mycobacterial, M. tuberculosis, metabolite, pumps, Pgp, P-gp, P-gp (P-glycoprotein), P-glycoprotein, P-glycoprotein (P-gp) inhibitor

Compound Identifiers

PubChem CID

155002