Norswertianin

SKU: orb3054605

Description

Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy.

Key Properties

• CAS Number: 22172-15-2
• MW: 260.2
• Purity: >98% (HPLC)
• Formula: C₁₃H₈O₆
• Solubility: DMSO : 13 mg/mL (49.96 mM; ultraphonic )

Bioactivity

• In Vitro:
  Norswertianin (12.5-50 μM; 48 hours) stimulats expression of GFAP and β-tubulin in U251 cells. Norswertianin (40 μM; 48 hours) causes the appearance of elongated processes in U251 cells, associated with G2/M cell cycle arrest. Norswertianin (40 μM; 48 hours) exhibits an increase in intracellular acidification and LC3 conversion.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only