Norethindrone acetate

SKU: orb1690485

Description

Norethindrone acetate

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51-98-9
• MW: 340.46
• Purity: 99.40% (May vary between batches)
• Formula: C₂₂H₂₈O₃
• SMILES: [H][C@@]12CC[C@@](OC(C)=O)(C#C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
• Target: Estrogen Receptor/ERR,Progesterone Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.69 mM);H2O:0.6 mg/mL (1.76 mM);DMSO:90 mg/mL (264.35 mM)

Bioactivity

• In Vivo:
  Norethindrone acetate effectively relieves dysmenorrhea and noncyclic pelvic pain. Norethindrone acetate as a standalone treatment option demonstrates excellent tolerability and efficacy in managing pain and bleeding associated with all stages of endometriosis. Experimental studies indicate that norethindrone acetate exhibits low acute toxicity in animals. Administration of norethindrone acetate alone to rodents at doses several times higher than those used in humans does not result in treatment-related mortality, hematological changes, behavioral alterations, or organ pathology. Administration of norethindrone acetate leads to significant and proportional reductions in the concentrations of triglycerides, cholesterol, and phospholipids in plasma lipoproteins with a density <1.006 in rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides in isolated hepatocytes obtained from fed rats.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

19-Norethindroneacetate, Norethindrone Acetate, ERR, EstrogenReceptor, estrogen receptor, Estrogen Receptor, progesterone receptor, Progesterone Receptor, ProgesteroneReceptor

Compound Identifiers

PubChem CID

5832