Norepinephrine bitartrate monohydrate

SKU: orb1309890

Description

Norepinephrine bitartrate monohydrate

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 108341-18-0
• MW: 337.28
• Purity: 99.57%
• Formula: C₈H₁₁NO₃·C₄H₆O₆·H₂O
• SMILES: O.OC(C(O)C(O)=O)C(O)=O.NCC(O)c1ccc(O)c(O)c1
• Target: Autophagy,Adrenergic Receptor,Endogenous Metabolite
• Solubility: H2O:31.9 mg/mL (94.58 mM);DMSO:50 mg/mL (148.24 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.93 mM)

Bioactivity

• Target IC50:
  β1-adrenoceptor:5.37 μM(EC50)
• In Vitro:
  Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations' and would, through an enhancement of ‘bottom-up' information processing at the expense of irrelevant ‘top-down' expectations, favor behavioral adjustment. Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects.
• Cell Research:
  Norepinephrine (NE)is dissolved in DMSO and stored, and then diluted with appropriate media before use. Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Noradrenaline bitartrate, Noradrenaline bitartrate Monohydrate, Noradrenaline bitartrate monohydrate, Norepinephrine bitartrate, Norepinephrine bitartrate monohydrate, Norepinephrine bitartrate Monohydrate, L-Noradrenaline bitartrate, inhibit, Levarterenol bitartrate, Levophed, Inhibitor, EndogenousMetabolite, Autophagy, Adrenergic Receptor, AdrenergicReceptor, Endogenous Metabolite, Beta Receptor, β1-adrenergic receptor

Compound Identifiers

PubChem CID

53399078