Nomegestrol

SKU: orb1705957

Description

Nomegestrol is a potent, selective, and orally active full agonist of the progesterone receptor. It exhibits anti-estrogenic, partial anti-androgenic, and anti-gonadotropic properties, making it a research tool for studying contraception, endometriosis, and meningioma in both in vitro and in vivo models.

Key Properties

• CAS Number: 58691-88-6
• MW: 328.45
• Formula: C₂₁H₂₈O₃
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@@]4(C(C(C)=C3)=CC(=O)CC4)[H])(CC1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]
• Target: Progesterone Receptor
• Solubility: DMSO:8 mg/mL (24.36 mM)

Bioactivity

• Target IC50:
  uterine progesterone receptor (rat):5.44 nM (Kd)
• In Vivo:
  In animal models, Nomegestrol demonstrated moderate antiandrogenic activity and strong antiestrogenic activity.
• In Vitro:
  Nomegestrol is a highly selective full agonist at the progesterone receptor but has little or no binding affinity for other steroid receptors such as the androgen and glucocorticoid receptors. Nomegestrol is a progestin with a high binding affinity for the progesterone receptor and a Kd of 5.44 nM for the rat uterine progesterone receptor.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ProgesteroneReceptor, Progesterone Receptor, progesterone receptor, TX 066 free base, Nomegestrol

Compound Identifiers

PubChem CID

68783