N,N'-Dimethylthiourea

SKU: orb1303214

Description

N,N'-Dimethylthiourea (DMTU) is an orally active hydroxyl radical scavenger isolated from garlic. It inhibits OH⁻ production by neutrophils in vitro and has demonstrated protective effects against stress-induced gastric lesions in rat models through its antioxidant and anti-inflammatory mechanisms.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 534-13-4
• MW: 104.17
• Purity: ≥98%
• Formula: C₃H₈N₂S
• SMILES: CNC(=S)NC
• Target: ROS,Reactive Oxygen Species,Antioxidant
• Solubility: DMSO:50 mg/mL (479.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (19.2 mM)

Bioactivity

• In Vivo:
  N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks . DMTU protects against WIRS-induced gastric mucosal lesions in rats by exerting its antioxidant action including ·OH scavenging and its anti-inflammatory action without affecting the stress response.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DMTU, Antioxidant, inhibit, orally, N,N' Dimethylthiourea, N,N'Dimethylthiourea, N,N'-Dimethylthiourea, Inhibitor, WIRS, scavengin

Compound Identifiers

PubChem CID

2723631