NMS-P937

SKU: orb1222915

Description

Onvansertib, also know as NMS-P937, PCM-075 and NMS1286937, is a n orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.

Research Area

Neuroscience

Key Properties

• CAS Number: 1034616-18-6
• MW: 532.52
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₇F₃N₈O₃
• SMILES: CN1CCN(CC1)c1cc(c(cc1)OC(F)(F)F)Nc1ncc2CCc3c(c2n1)n(nc3C(=O)N)CCO
• Target: PLK1| PLK2| PLK3
• Solubility: DMSO : 21 mg/mL. 39.44 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PCM-075 | PCM 075 | NMS1286937

Quick Database Links

Gene Symbol

PLK1| PLK2| PLK3