NMS-P715

SKU: orb1309330

Description

NMS-P715 is a potent, ATP-competitive small molecule inhibitor of MPS1 kinase with high selectivity and an IC50 of 182 nM. It is a valuable research tool for studying mitosis, chromosome segregation, and cancer biology in both cellular and in vivo models.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1202055-32-0
• MW: 676.73
• Purity: 99.84%
• Formula: C₃₅H₃₉F₃N₈O₃
• SMILES: CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NC3CCN(C)CC3)nc-21
• Target: Kinesin,Casein Kinase,MAPK,MELK
• Solubility: DMSO:2 mg/mL (2.96 mM)

Bioactivity

• Target IC50:
  Mps1:182 nM|CK2:5.7 μM|MELK:6.01 μM|NEK6:6.02 μM
• In Vivo:
  NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model.
• In Vitro:
  NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Casein Kinase, CaseinKinase, CK2, Monopolar spindle 1, Mps1, inhibit, NMS-P 715, NMS P715, NMSP715, NMS-P715, NMS-P-715, NEK6, MELK, Inhibitor

Compound Identifiers

PubChem CID

44556162