NMS-P626

SKU: orb2665466

Description

NMS-P626 is a potent pan-TRK inhibitor with IC50 values of 8, 7, and 3 nM for TRKA, TRKB, and TRKC, respectively. It demonstrates anti-proliferative activity in KM12 colorectal cancer cells (IC50=19 nM) by blocking TPM3-TRKA phosphorylation and downstream signaling, making it a useful tool for oncology research.

Research Area

Neuroscience, Signal Transduction

Key Properties

• CAS Number: 942471-37-6
• MW: 603.68
• Formula: C₂₈H₃₅F₂N₇O₄S
• SMILES: N(C(=O)C1=C(N[C@@H](COC)C)C=C(C=C1)N2CCN(C)CC2)C=3C4=C(NN3)CCN(S(=O)(=O)C5=CC(F)=CC(F)=C5)C4
• Target: Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16665788