NMS-P118

SKU: orb1302830

Description

NMS-P118

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1262417-51-5
• MW: 395.42
• Purity: 98.87%
• Formula: C₂₀H₂₄F₃N₃O₂
• SMILES: NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12
• Target: PARP
• Solubility: DMSO:16 mg/mL (40.46 mM)

Bioactivity

• Target IC50:
  PARP1:9 nM (Kd)|PARP2:1390 nM (Kd)
• In Vitro:
  NMS-P118 proved to be a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, respectively. Cocrystal structures of 20by with both PARP-1 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP, PARP1, PARP2, NMS-P 118, NMSP118, NMS-P118, NMS-P-118, NMS P118, inhibit, Inhibitor, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

49843531