NMS-859

SKU: orb1309331

Description

NMS-859 is a potent, covalent inhibitor of VCP/p97, demonstrating consistent cellular activity with IC50 values of approximately 0.37 μM across physiological ATP concentrations. This small molecule is a valuable research tool for investigating VCP-related pathways in cancer, neurodegenerative diseases, and in vitro protein homeostasis studies.

Research Area

Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 1449236-96-7
• MW: 349.79
• Purity: 98.20% (May vary between batches)
• Formula: C₁₅H₁₂ClN₃O₃S
• SMILES: ClCC(=O)OC1=CC=CC(NC2=NS(=O)(=O)C3=C2C=CC=C3)=C1
• Target: p97,Others
• Solubility: DMSO:3.5 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.86 mM)

Bioactivity

• Target IC50:
  Cellular p97 (60 μM ATP):370 nM |Cellular p97 (1 mM ATP):360 nM
• In Vitro:
  NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

valosin-containing protein (VCP)/p97, ZINC 169324353, ZINC169324353, ZINC-169324353, NMS 859, NMS859, NMS-859

Compound Identifiers

PubChem CID

4276099