NMac1

SKU: orb1738523

Description

NMac1 (cassumunene) is a natural compound derived from Zingiber cassumunar that activates Nm23-H1's NDPK activity, demonstrating anti-metastatic effects in vitro and inhibiting breast cancer metastasis in vivo. This makes it a valuable small molecule for oncology research, particularly in studying metastasis suppression mechanisms.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1332290-68-2
• MW: 380.48
• Purity: 99.40% (May vary between batches)
• Formula: C₂₄H₂₈O₄
• SMILES: C(=C/C1=CC(OC)=C(OC)C=C1)\C2C(C=CCC2)C3=CC(OC)=C(OC)C=C3
• Target: ROS,mTOR,Others,Ras,ERK,OXPHOS,AMPK

Bioactivity

• Target IC50:
  NDPK:10.7 μM (EC50)
• In Vivo:
  In NOD/SCID mice injected in situ with MDA-MB-231-LUS-D3H2LN cells, treatment with NMac1 (10 mg/Kg, 3 weeks) significantly inhibited breast cancer metastasis without affecting primary tumor size.
• In Vitro:
  NMac1 is a potent activator of NDPK protein, activating NDPK activity of recombinant Nm23-H1 in a dose-dependent manner with an EC50 of 10.7 μM. The morphological changes observed in MDA-MB-231 cells after treatment with NMac1 (25 μM) included substantial changes in the original height mesenchymal type (with a large number of folds) to a non-metastatic form with reduced folds and increased cell coverage. NMac1 significantly reduced invasion and migration of MDA-MB-231 cells in a dose-dependent manner without affecting their proliferation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Irinotecan Carboxylate Sodium Salt, NMac1, Nm23 activator 1

Compound Identifiers

PubChem CID

70698133