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NM107

SKU: orb1225717

Description

A nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells; The active component of NM283.HCV Infection Phase 2 Discontinued.

Images & Validation

Key Properties

CAS Number20724-73-6
MW257.2432
Purity>98% (HPLC)
FormulaC10H15N3O5
SMILESOC[C@@H]1[C@H]([C@@]([C@H](N2C(N=C(C=C2)N)=O)O1)(C)O)O
TargetHCV
Solubility10 mM in DMSO

Bioactivity

In Vitro
RT-PCR Cell line: Huh7-1 cells and cell culture-propagated HCV (HCVcc). Concentration: 25 μM. Incubation time: 24 hours. Result: Extracellular virus titers declined in parallel with intracellular RNA levels.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

2'-C-Methylcytidine | NM-107 | Valopicitabine

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Protocol Information

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200 mg
500 mg
2 mg
$ 70.00
5 mg
$ 110.00
10 mg
$ 140.00
50 mg
$ 260.00
100 mg
$ 320.00