NM-3

SKU: orb1741514

Description

NM-3 is an orally bioavailable small molecule with anti-angiogenic and anti-tumor properties. It functions as a radiation sensitizer in experimental models by inhibiting VEGF-induced endothelial cell proliferation and inducing ROS-mediated apoptosis. Its research applications include studying angiogenesis, tumor response to radiotherapy, and combination therapies in both in vitro and in vivo settings.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 181427-78-1
• MW: 264.23
• Purity: 99.89% (May vary between batches)
• Formula: C₁₃H₁₂O₆
• SMILES: O=C1C=2C(C=C(C(C(O)=O)C)O1)=CC(OC)=CC2O
• Target: MDM-2/p53,Reactive Oxygen Species,Apoptosis,Others
• Solubility: DMSO:27.5 mg/mL (104.08 mM)

Bioactivity

• In Vivo:
  C57BL/6 female mice bearing LLC tumors were given injections for 4 consecutive days with NM-3 (25 mg/kg/day) and treated with IR (20 Gy) for 2 consecutive days. Combined treatment with NM-3 and IR significantly reduced mean tumor volume compared with either treatment alone. An increase in local tumor control was also observed in LLC tumors in mice receiving NM-3/IR therapy. When athymic nude mice bearing Seg-1 tumor xenografts were treated with NM-3 (100 mg/kg/day for 4 days) and 20 Gy (four 5 Gy fractions), significant tumor regression was observed after combined treatment (NM-3 and IR) compared with IR alone. Importantly, no increase in systemic or local tissue toxicity was observed after combined treatment (NM-3 and IR) when compared with IR alone. The bioavailability and nontoxic profile of NM-3 suggests that the efficacy of this agent should be tested in clinical radiotherapy.
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• In Vitro:
  NM-3 (100 ng/ml) is cytotoxic to human umbilical vein endothelial cells (HUVECs) but not to Lewis lung carcinoma (LLC) cells nor Seg-1, esophageal adenocarcinoma cells, in clonogenic survival assays (1,000 ng/ml ; 4h).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isocoumarin NM-3, NM 3, NM3, Apoptosis, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

5493470