NLX-204 hydrochloride（2170405-10-2 free base）

SKU: orb1219324

Description

NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein. Preliminary in vivo studies confirmed its promising pharmacokinetic profile. NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.

Key Properties

• Target: 5-HT Receptor
• Molecular Weight: 409.13
• Purity: >98% (HPLC)
• CAS Number: ——
• Formula: C₂₀H₂₃Cl₂F₂N₃O₂
• SMILES: [H]Cl.O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC=C3)(F)CC2

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor