NLRP3 modulator 8

SKU: orb3136978

Description

NLRP3 modulator 8 (Compound 14) is an NLRP3 regulator that can significantly degrade the NEK7 protein (DC50 = 9 nM). In macrophages, NLRP3 modulator 8 can inhibit the activity of caspase-1 in a dose-dependent manner and reduce the release of IL-1β triggered by the activation of the NLRP3 inflammasome. NLRP3 modulator 8 is applicable for the research of various diseases, including autoinflammatory and autoimmune diseases, neurodegenerative diseases, as well as cardiovascular and metabolic-related diseases, etc.

Research Area

Cell Biology

Key Properties

• CAS Number: 3069891-88-6
• MW: 453.3
• Formula: C₂₀H₁₉Cl₂FN₄O₃
• SMILES: FC1=CN=C(C(C)(C)C(NCC2=CC(Cl)=C(C3C(NC(CC3)=O)=O)C(Cl)=C2)=O)N=C1
• Target: NOD

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NOD