NLRP3-IN-86

SKU: orb3175103

Description

NLRP3-IN-86 (Compound 8a), a derivative of Songorine, is a potent and selective inhibitor of the NLRP3 inflammasome. It effectively reduces lactate dehydrogenase (LDH) release induced by LPS and Nigericin, with an IC50 of 2.69 μM in THP-1 cells and 1.75 μM in J774A.1 cells. Additionally, NLRP3-IN-86 inhibits the cleavage of gasdermin D (GSDMD) and the secretion of IL-1β, effectively suppressing pyroptosis. This compound is applicable for inflammation-related research.

Key Properties

• CAS Number: 2361570-54-7
• MW: 355.48
• Formula: C₂₂H₂₉NO₃
• SMILES: O[C@@H]1[C@]23[C@]4([C@@]5([C@@]6(C2(N(CC)C[C@@](C)([C@]3(C6)[H])CC1)[H])[H])C[C@@](C(=O)C4)(C(=C)C5=O)[H])[H]
• Target: Pyroptosis,Dehydrogenase,NOD-like Receptor (NLR),Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Pyroptosis,Dehydrogenase,NOD-like Receptor (NLR),Interleukin