NLRP3-IN-83

SKU: orb3173055

Description

NLRP3-IN-83 is a selective and orally active inhibitor of NLRP3 inflammasome activation. It effectively inhibits IL-1β activity by blocking NLRP3, with an IC50 of 1.4 μM, independently of NF-κB signaling. NLRP3-IN-83 exhibits a slight inhibitory effect on the AIM2 inflammasome pathway and no effect on the NLRC4 inflammasome. It prevents pyroptosis and demonstrates significant anti-inflammatory effects in a model of ulcerative colitis. NLRP3-IN-83 is applicable for research in inflammatory bowel disease (IBD).

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• Target: Interleukin,Pyroptosis,NOD-like Receptor (NLR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,Pyroptosis,NOD-like Receptor (NLR)