NLRP3-IN-81

SKU: orb3135122

Description

NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 2922814-85-3
• MW: 372.36
• Formula: C₁₆H₁₅F₃N₂O₃S
• SMILES: O=S(=O)(C1=NN=C(C=C1)C=2C=CC(=CC2O)C(F)(F)F)C3CCCC3
• Target: Pyroptosis,NOD-like Receptor (NLR),Caspase,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Pyroptosis,NOD-like Receptor (NLR),Caspase,Interleukin