NLRP3-IN-78

SKU: orb3028397

Description

NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 477546-27-3
• MW: 390.222
• Formula: C₁₂H₅Cl₂N₃O₄S₂
• SMILES: [O-][N+](=O)C1=CC=C(O1)C(=O)NC1=NC(=CS1)C1=C(Cl)SC(Cl)=C1
• Target: Pyroptosis,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Pyroptosis,NF-κB