NLRP3-IN-76

SKU: orb3028419

Description

NLRP3-IN-76 is an orally active NLRP3 inhibitor that suppresses the production of NO and reduces the mRNA levels of pro-inflammatory cytokines (iNOS, IL-6, IL-1β, and TNFα). It exerts anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and the NF-κB signaling pathway. Furthermore, NLRP3-IN-76 can ameliorate DSS-induced colitis and is applicable for studying inflammatory bowel disease (IBD).

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• Target: NF-κB,Interleukin,NO Synthase,NOD-like Receptor (NLR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB,Interleukin,NO Synthase,NOD-like Receptor (NLR)