NLRP3-IN-32

SKU: orb3133835

Description

NLRP3-IN-32 (compound 7a) is a derivative of 3,4-dihydronaphthalene-1(2H)-one and acts as an inhibitor of the NLRP3 inflammasome. It obstructs the assembly and activation of the NLRP3 inflammasome by downregulating the expression of NLRP3 and the apoptosis-associated speck-like protein containing a CARD (ASC), thereby reducing the production of reactive oxygen species (ROS) and other inflammatory mediators. Additionally, NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65, as well as the nuclear translocation of p65, thus suppressing NF-κB signaling.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• Formula: C₂₁H₂₂BrN₃O
• Target: NF-κB,IκB/IKK,Reactive Oxygen Species,NOD-like Receptor (NLR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB,IκB/IKK,Reactive Oxygen Species,NOD-like Receptor (NLR)