NLRP3-IN-20

SKU: orb1944181

Description

NLRP3-IN-20 is a potent and orally bioavailable NLRP3 inflammasome inhibitor, demonstrating an IC50 of 25 nM against IL-1β release. It has shown significant therapeutic efficacy in preclinical models of inflammatory diseases, including non-alcoholic steatohepatitis, septic shock, and colitis.

Research Area

Cell Biology

Key Properties

• CAS Number: 2428478-22-0
• MW: 413.53
• Formula: C₂₂H₂₇N₃O₃S
• SMILES: N(C(NS(=O)(=O)C1=CC=C(CN(C)C)C=C1)=O)C2=C3C(=CC4=C2CCC4)CCC3
• Target: NOD-like Receptor (NLR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

153186542