NLRP3i

SKU: orb1304400

Description

NLRP3-IN-2 is a chemical intermediate for glibenclamide synthesis that specifically inhibits NLRP3 inflammasome assembly in cardiomyocytes. It has been shown to reduce myocardial infarct size in mouse models of ischemia/reperfusion injury without affecting metabolic parameters, making it a useful research tool for studying cardiovascular inflammation.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 16673-34-0
• MW: 368.8
• Purity: >98%
• Formula: C₁₆H₁₇ClN₂O₄S
• SMILES: COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(N)(=O)=O
• Target: Inflammasome
• Solubility: Soluble in DMSO up to 45 mg/ml

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JC121

Compound Identifiers

PubChem CID

85542