NLRP3-IN-2

SKU: orb1304400

Description

NLRP3-IN-2 is a chemical intermediate for glibenclamide synthesis that specifically inhibits NLRP3 inflammasome assembly in cardiomyocytes. It has been shown to reduce myocardial infarct size in mouse models of ischemia/reperfusion injury without affecting metabolic parameters, making it a useful research tool for studying cardiovascular inflammation.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 16673-34-0
• MW: 368.84
• Purity: 98.98% (May vary between batches)
• Formula: C₁₆H₁₇ClN₂O₄S
• SMILES: COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(N)(=O)=O
• Target: NOD,NOD-like Receptor (NLR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.42 mM);DMSO:55 mg/mL (149.12 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

acute, 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide, NLR, NLRP3 IN 2, NLRP3 Inflammasome Inhibitor I, NLRP3IN2, NLRP-3-IN-2, NLRP3-IN-2, NLRP3, NOD-like Receptor (NLR), NODlike Receptor (NLR), NODlikeReceptor, NOD-like Receptor, NODlikeReceptor(NLR), myocardial, inhibit, ischemia, inflammasome, infarction, Inhibitor, reperfusion

Compound Identifiers

PubChem CID

85542