NLRP3-IN-11

SKU: orb1688906

Description

NLRP3-IN-11 is a small molecule inhibitor of the NLRP3 inflammasome, exhibiting anti-inflammatory properties. It is utilized in research models for inflammatory diseases, including studies on atherosclerosis and Parkinson's disease pathogenesis in both cellular and animal systems.

Research Area

Cell Biology

Key Properties

• CAS Number: 2769040-91-5
• MW: 344.8
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₁₇ClN₄O₂
• SMILES: N(CC(C)(C)O)C=1C2=C(C(=NN1)C3=C(O)C=C(Cl)C=C3)C=CN=C2
• Target: NOD,NOD-like Receptor (NLR)
• Solubility: DMSO:100 mg/mL (290.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.6 mM)

Bioactivity

• Target IC50:
  NLRP3:<0.3 μM
• In Vitro:
  NLRP3-IN-11 exhibits biological activity with an IC50 value of <0.3 μM in a human PBMC NLRP3 assay .

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NLRP3

Compound Identifiers

PubChem CID

164754476