NLG802

SKU: orb1691281

Description

NLG802 is an orally administered prodrug that is metabolized to the active IDO pathway inhibitor indoximod. This small molecule is used in research to investigate immunomodulation and antitumor responses in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2071683-99-1
• MW: 395.92
• Purity: 99.61% (May vary between batches)
• Formula: C₂₀H₃₀ClN₃O₃
• SMILES: Cl.CCOC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CC(C)C
• Target: Indoleamine 2,3-Dioxygenase (IDO),IDO
• Solubility: DMSO:225 mg/mL (568.3 mM)

Bioactivity

• In Vitro:
  NLG802 showed moderate direct (IC50 5 μM) and time dependent (7-fold shift) inhibition of CYP3A4, weak inhibition to CYP2D6 (IC50 19 μM) and CYP2C19 (IC50 47 μM), no inhibition of CYP450 1A2, 2B6, 2C8 and 2C9 (IC50 > 50 μM) and no induction of CYP1A2, 2B6 or 3A4 in human hepatocytes. NLG802 showed moderate inhibition of P-gp transporter activity in MDR1-MDCKII cells (IC50 27 μM), does not inhibit the anion and cation transporters OATP1B1, OATP1B3, OAT1, OAT3, OCT1 and OCT2 in HEK293 cells expressing these transporters (IC50 > 50 μM) or the BRCP transporter in Caco-2 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IDO, Indoleamine 2,3Dioxygenase (IDO), Indoleamine 2,3-Dioxygenase, Indoleamine2,3Dioxygenase, Indoleamine2,3Dioxygenase(IDO), NLG 802, NLG802, NLG-802

Compound Identifiers

PubChem CID

162623745