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NL13

SKU: orb2663622

Description

NL13 is a PLK4 inhibitor (IC50=2.32 µM) that reduces viability in prostate cancer cell lines (PC3, DU145) and inhibits tumor growth in mouse models. Its mechanism involves downregulating the AKT/CCNB1/CDK1 pathway, inducing G2/M arrest and caspase-mediated apoptosis, making it a useful research tool for oncology studies.

Research Area

Cell Biology, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

MW400.3
FormulaC22H19Cl2NO2
TargetCDK,Akt,PLK,Apoptosis,Caspase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

NL13 (orb2663622)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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