NKY80

SKU: orb1706905

Description

NKY80 is a selective, non-competitive inhibitor of adenylyl cyclase, with highest potency against the type V isoform (IC50 = 8.3 µM). This small molecule is a valuable research tool for investigating cAMP signaling pathways in cardiovascular and pulmonary research, applicable in both in vitro and ex vivo tissue studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 299442-43-6
• MW: 229.23
• Purity: 99.88%
• Formula: C₁₂H₁₁N₃O₂
• SMILES: NC1=NC2=C(C=N1)C(=O)CC(C2)C1=CC=CO1
• Target: AChR,Adenylyl Cyclase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (21.81 mM);DMSO:225 mg/mL (981.55 mM)

Bioactivity

• Target IC50:
  AC type III:132 μM|AC type V:8.3 μM|AC type II:1.7 mM
• In Vitro:
  NKY80 (20 μM) blocks the increase in LVP and ventricular cAMP levels. NKY80 (20 μM; 2 hours) completely blocks the elevations in both cAMP content and renin release from isolated JG cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC type II, AC type III, AC type V, Adenylyl cyclase, Adenylyl cyclase (AC), Adenylylcyclase, Adenylyl cyclase type V Inhibitor, NKY 80, NKY80, NKY-80

Compound Identifiers

PubChem CID

2772368