NKY-80

SKU: orb1706905

Description

NKY80 is a selective, non-competitive inhibitor of adenylyl cyclase, with highest potency against the type V isoform (IC50 = 8.3 µM). This small molecule is a valuable research tool for investigating cAMP signaling pathways in cardiovascular and pulmonary research, applicable in both in vitro and ex vivo tissue studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 299442-43-6
• MW: 229.24
• Purity: >98%
• Formula: C₁₂H₁₁N₃O₂
• SMILES: NC1=NC2=C(C=N1)C(=O)CC(C2)C1=CC=CO1
• Target: Adenylyl cyclase
• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).

Bioactivity

• Target IC50:
  AC type III:132 μM|AC type V:8.3 μM|AC type II:1.7 mM
• In Vitro:
  NKY80 (20 μM) blocks the increase in LVP and ventricular cAMP levels. NKY80 (20 μM; 2 hours) completely blocks the elevations in both cAMP content and renin release from isolated JG cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC type II, AC type III, AC type V, Adenylyl cyclase, Adenylyl cyclase (AC), Adenylylcyclase, Adenylyl cyclase type V Inhibitor, NKY 80, NKY80, NKY-80

Compound Identifiers

PubChem CID

2772368