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NK7-902 TFA

SKU: orb3136778

Description

NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

TargetMolecular Glues,MAPK,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

NK7-902 TFA (orb3136778)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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