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NK7-902 diTFA

SKU: orb3175262

Description

NK7-902 (diTFA) is a CRBN molecular glue degrader targeting NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, though it only partially inhibits NLRP3-dependent IL-1β production. NK7-902 (diTFA) induces deep and sustained degradation of NEK7 but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. Additionally, NK7-902 (diTFA) exhibits activity in mouse systems.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

TargetMAPK,Molecular Glues

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information