Nitroflurbiprofen

SKU: orb1307960

Description

Nitroflurbiprofen is a nitric oxide (NO)-donating cyclooxygenase (COX) inhibitor. It is a research compound used to study vascular dysfunction, particularly for investigating the reduction of elevated intrahepatic vascular resistance in preclinical models of portal hypertension and cirrhosis.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 158836-71-6
• MW: 361.36
• Purity: 99.88% (May vary between batches)
• Formula: C₁₉H₂₀FNO₅
• SMILES: CC(C(=O)OCCCCO[N+]([O-])=O)c1ccc(c(F)c1)-c1ccccc1
• Target: COX
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.84 mM);DMSO:55 mg/mL (152.2 mM)

Bioactivity

• In Vivo:
  Nitroflurbiprofen (45 mg/kg; i.p.) improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX, Cyclooxygenase, inhibit, Nitroxybutyl flurbiprofen, Nitroflurbiprofen, NO-flurbiprofen, Inhibitor, HCT1206, HCT-1206, HCT 1206

Compound Identifiers

PubChem CID

119387