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Nisin Z
Catalog Number: orb1981185
| Catalog Number | orb1981185 |
|---|---|
| Category | Small Molecules |
| Description | Nisin Z has anti-inflammatory activity and reduces pro-inflammatory cytokine release by inhibiting activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways, attenuating lipopolysaccharide-induced mastitis through inhibition of the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways. |
| MW | 3331.03 |
| CAS Number | 137061-46-2 |
| Formula | C141H229N41O38S7 |
| SMILES | O=C(NC(C(=O)O)CCCCN)C(=C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1NC(=O)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C3NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C4NC(=O)CNC(=O)C5N(C(=O)C(NC(=O)C6NC(=O)C(NC(=O)C(=C)NC(=O)C(NC(=O)C(NC(=O)C(=CC)NC(=O)C(N)C(C)CC)CSC6)C(C)CC)CC(C)C)C(SC4)C)CCC5)CCCCN)C(SC3)C)C)CC(C)C)CCSC)CC(=O)N)CCSC)CCCCN)C(SC2)C)C)C(SC1)C)CC(=O)N)CO)C(C)CC)CC7=CN=CN7)C(C)C |
| Storage | -20°C |
| Research Area | Signal Transduction |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
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nisZ Protein [orb1477299]
Greater than 85% as determined by SDS-PAGE.
18.8 kDa
E.coli
1 mg, 20 μg, 100 μg
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
