Nirogacestat dihydrobromide

SKU: orb1692162

Description

This potent γ-secretase inhibitor demonstrates high activity with IC50 values of 1.2 nM (cellular) and 6.2 nM (cell-free). It effectively lowers Aβ levels in the brain, cerebrospinal fluid, and plasma in rodent models, making it a valuable research tool for Alzheimer's disease and amyloid pathology studies in both in vitro and in vivo settings.

Research Area

Cell Biology, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1962925-29-6
• MW: 651.47
• Purity: 99.07% (May vary between batches)
• Formula: C₂₇H₄₃Br₂F₂N₅O
• SMILES: FC1=C2C(CC[C@@H](C2)N[C@@H](CCC)C(NC3=CN(C=N3)C(C)(C)CNCC(C)(C)C)=O)=CC(F)=C1.Br.Br
• Target: Gamma-secretase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

121513889