Nirogacestat dihydrobromide

SKU: orb1692162

Description

This potent γ-secretase inhibitor demonstrates high activity with IC50 values of 1.2 nM (cellular) and 6.2 nM (cell-free). It effectively lowers Aβ levels in the brain, cerebrospinal fluid, and plasma in rodent models, making it a valuable research tool for Alzheimer's disease and amyloid pathology studies in both in vitro and in vivo settings.

Research Area

Cell Biology, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1962925-29-6
• MW: 651.48
• Formula: C₂₇H₄₃Br₂F₂N₅O
• SMILES: Br.Br.CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(cn1)C(C)(C)CNCC(C)(C)C
• Target: Others,Gamma-secretase,Apoptosis

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

121513889