Niraparib tosylate monohyrate

SKU: orb1298065

Description

Niraparib (MK-4827) is a potent PARP inhibitor that disrupts the base-excision DNA repair pathway, leading to genomic instability and apoptosis in cancer cells. It is widely used in oncology research, particularly for studying BRCA-mutant cancers, and has demonstrated efficacy in both in vitro assays and in vivo tumor models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1613220-15-7
• MW: 510.61
• Purity: 99.99%
• Formula: C₂₆H₃₀N₄O₅S
• SMILES: CC1=CC=C(S(=O)(O)=O)C=C1.O=C(N)C(C2=N3)=CC=CC2=CN3C(C=C4)=CC=C4[C@@H]5CCCNC5.O
• Target: PARP,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.92 mM);H2O:1 mg/mL (1.96 mM);DMSO:247.5 mg/mL (484.71 mM)

Bioactivity

• Target IC50:
  PARP3:1300 nM|PARP2:2.1 nM|PARP1:3.8 nM|PARP4:330 nM|tankyrase 1:570 nM

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, MK-4827 tosylate, Niraparib tosylate, Niraparib tosylate monohyrate, orally, lung, PARP, DNA, damage, breast, anti-tumor, Apoptosis, cancer, bioavailable, poly ADP ribose polymerase, ovarian

Compound Identifiers

PubChem CID

74763937