Niraparib (R-enantiomer)

SKU: orb1309416

Description

MK 4827 R-enantiomer is the R-enantiomeric form of niraparib, functioning as a potent PARP1 inhibitor with an IC50 of 2.4 nM. This compound is utilized in cancer research, particularly for studying synthetic lethality in BRCA-deficient models, and has been investigated in both cellular assays and in vivo xenograft studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1038915-58-0
• MW: 320.39
• Purity: 99.83% (May vary between batches)
• Formula: C₁₉H₂₀N₄O
• SMILES: NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@H]1CCCNC1
• Target: PARP
• Solubility: DMSO:30 mg/mL (93.64 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.24 mM)

Bioactivity

• Target IC50:
  PARP1:2.4 nM
• In Vitro:
  Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, poly ADP ribose polymerase, Niraparib, Niraparib (R enantiomer), Niraparib (Renantiomer), Niraparib (R-enantiomer), Niraparib R-enantiomer, MK-4827, MK 4827, MK 4827 (R-enantiomer), MK4827, PARP, PARP1, Inhibitor

Compound Identifiers

PubChem CID

24958199