Nimbolide

SKU: orb1307963

Description

Nimbolide is a neem-derived triterpenoid that acts as a multi-pathway inhibitor, suppressing CDK4/6 kinase activity and disrupting NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling. Its induction of apoptosis via NF-κB inactivation supports its research use in oncology, with demonstrated effects in both cellular and animal models of cancer.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 25990-37-8
• MW: 466.52
• Purity: 99.40% (May vary between batches)
• Formula: C₂₇H₃₀O₇
• SMILES: C[C@]12[C@]3([C@]([C@@]4([C@](C)([C@@H]1CC(OC)=O)C=5[C@](O4)(C[C@H](C5C)C=6C=COC6)[H])[H])(OC(=O)[C@]3(C)C=CC2=O)[H])[H]
• Target: NF-κB,Apoptosis,Wnt/beta-catenin,CDK
• Solubility: DMSO:60 mg/mL (128.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.14 mM)

Bioactivity

• Target IC50:
  N1E-115 cells viability:4-10 μM|MCF-7 cells proliferation:5.04 ± 0.25 μM|Parasites:8.13-9.4 μM|MDA-MB-231 cells proliferation:1.97 ± 0.24 μM

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK, CDK4, CDK6, Cyclin dependent kinase, Apoptosis, Inhibitor, inhibit, NFkB, NF-kB, NF-κB, NFκB, Nimbolide, Nuclear factor-kappaB, Nuclear factor-κB

Compound Identifiers

PubChem CID

12313376