Nilofabicin

SKU: orb1306955

Description

Nilofabicin

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 934628-27-0
• MW: 340.44
• Purity: 98.66%
• Formula: C₁₉H₂₀N₂O₂S
• SMILES: Cc1c(N)cccc1Cn1ccc(OCCc2cccs2)cc1=O
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:95 mg/mL (279.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.69 mM)

Bioactivity

• Target IC50:
  S. aureus:0.5 μg/ml(MIC90)
• In Vitro:
  Nilofabicin had an MIC90 of 0.5 μg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin. Among 203 strains of Staphylococcus aureus, the MICs of Nilofabicin were 0.06 to 1.0 μg/ml, with MIC(50) and MIC(90) values of 0.25 μg/ml each. All strains were susceptible to linezolid and quinupristin-dalfopristin (MICs, 0.25 to 2.0 μg/ml).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CG400549, CG-400549, CG0549, CG-0549, CG 0549, CG 400549, Bacterial, Antibiotic, enoyl-acyl carrier protein reductase (FabI), Inhibitor, inhibit, Nilofabicin, S. aureus

Compound Identifiers

PubChem CID

11844916